Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

76
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
76
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

2.4K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.4K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

865
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
865
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

291
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
291
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

5.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.2K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

33
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
33
このページは機械翻訳されています。他のページは英語で表示される場合があります。View in English
  1. ホーム
  2. 研究分野
  3. 生物医学と臨床科学
  4. 心血管医学と血液学
  5. 心臓病 (心血管疾患を含む)
  6. 高密度リポタンパク質 第2部 病気の状態が機能に与える影響

高密度リポタンパク質 第2部 病気の状態が機能に与える影響

Anna Gluba-Sagr1, Robert Olszewski2, Beata Franczyk1

  • 1Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 113 Żeromskiego Street, 90-549 Lodz, Poland.

American journal of preventive cardiology
|September 2, 2025

関連する実験動画

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.7K
Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment
07:12

Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment

Published on: June 2, 2023

7.3K

PubMed で要約を見る

まとめ
この要約は機械生成です。

高密度リポタンパク質 (HDL) は,個人の健康に影響される,有益で有害な複雑な機能を持っています. HDL コレステロールを増やすだけでは 心血管の健康は改善しないかもしれません

科学分野:

  • 生物化学
  • 心血管科学
  • 脂質代謝

背景:

  • 高密度脂質 (HDL) は,伝統的に動脈硬化症に対する保護として見られています.
  • HDL粒子は,タンパク質,脂質,マイクロRNAを含む複雑な荷物を有しており,それはその多様な機能を決定します.
  • HDLの機能はダイナミックで,個々の遺伝子と代謝状態に影響されます.

研究 の 目的:

  • 動脈保護の概念を超えて,HDLの多面的な役割を調査する.
  • HDLの組成の変化が,様々な疾患状態におけるその機能にどのように影響するかを調査する.
  • HDL,全身の炎症,酸化ストレスとの複雑な関係を理解する.

主な方法:

  • HDLの組成と機能に関する既存の文献のレビュー
  • 代謝および遺伝因子がHDLの性質をどのように変化させるかを分析する.
  • 心血管疾患や糖尿病などの特定の疾患の文脈でのHDL変化の検査

主要な成果:

  • HDLの機能性は,分子積載と個人の代謝/遺伝的背景によって非常に変動します.
  • 炎症と酸化ストレスによって特徴づけられる疾患は,HDLの組成を大きく変化させ,その有益な機能を損なう.
  • 急性相反応剤は,炎症反応の間,HDLの重要な抗酸化分子を置き換えることができます.
キーワード:
動脈硬化症流行病学高密度の脂質タンパク質炎症

関連する実験動画

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.7K
Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment
07:12

Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment

Published on: June 2, 2023

7.3K

結論:

  • 心血管の健康における HDL の役割は,これまで考えられていたよりも複雑で,有益な効果と有害な効果の両方がある可能性があります.
  • HDLを標的とする治療戦略は,コレステロールレベルにのみ焦点を当てるのではなく,疾患状態におけるその機能の変化を考慮すべきである.
  • HDLの複雑な機能を完全に理解し,病気の管理のためのその可能性を活用するには,さらなる研究が必要です.
酸化
コレステロールの逆輸送
トロンボシス