非エオシノフィルの食道炎 エオシノフィルの食道炎より韓国人の子供に多い:新しい診断基準と命名に基づいた多センター研究
Kunsong Lee1, Ben Kang2, Eun Sil Kim3
1Department of Pediatrics, Dankook University College of Medicine, Cheonan, Republic of Korea.
Frontiers in pediatrics
|September 2, 2025
まとめ
韓国人の子供では,欧米諸国とは異なり,エオシノフィルのないEGIDはEoEよりも一般的です. エオシノフィルとカルプロテクチンのレベルが高かったのは,食道に感染した非EoE EGID患者で観察された.
科学分野:
- 胃腸内科
- 小児医学
- 免疫学
背景:
- エオシノフィル性胃腸疾患 (EGID) は,エオシノフィル性胃腸の浸透を含む慢性炎症性疾患である.
- 最近の進歩により,EGIDの新しい分類と診断ガイドラインが生まれました.
研究 の 目的:
- 韓国における小児性EGIDの疫学的および臨床的特徴を調査する.
- 韓国の小児科コホートにおけるEGIDの最新の診断基準を適用する.
主な方法:
- 胃腸内視鏡検査を受けた小児患者 (0~18歳) の遡及分析 (2010~2023年).
- 新しい基準に基づいて,エオシノフィル性食道炎 (EoE) と非EoE EGID (エオシノフィル性胃炎,腸炎,大腸炎) に分類する.
- 臨床的,実験的,内視的発見の分析
主要な成果:
- EGIDは4, 972件の小児手術の1. 3%で診断され,EoE以外のEGID (65. 1%) はEoE (34. 9%) より一般的であった.
- エオシノフィルの胃炎は,最も一般的な非EoEサブタイプ (33. 3%) で,次にエオシノフィルの腸炎 (20. 6%) であった.
- 外周エオシノフィルの数と糞便のカルプロテクチンは,エオエと比べて食道に感染した非エオエ EGID 群で高かった.
結論:
- 韓国の小児EGID疫学では,EoE以外のEGIDの流行率がEoEよりも高く,欧米のデータとは異なる.
- エオシノフィルとカルプロテクチンの上昇を含む特異的な臨床および検査結果が,食道に関わる韓国人の小児非EoE EGIDで観察されています.
関連する概念動画
Gastroesophageal Reflux Disease II: Clinical Features and Management
156
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
156
Esophageal Strictures-I: Introduction
264
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
264
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
439
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
439
Barrett Esophagus-II: Clinical Manifestations and Management
292
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
292
Barrett Esophagus-I: Introduction
198
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
198
Esophageal Strictures-II: Clinical Features and Management
156
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
156


