腸内微生物群とサルコペニアの食事指数の関連:体丸さ指数の媒介効果
Shan Li1, Huanhuan Huang1, Haoning Shi1
1Department of Nursing, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Innovation in aging
|September 2, 2025
まとめ
腸内微生物群の栄養指数 (DI-GM) に反映された健康的な食生活は,サルコペニアのリスクの低下と関連しています. ボディラウンドネス・インデックス (BRI) は,この食事と腸内微生物とサルコペニアの関係を有意に媒介する.
科学分野:
- 代謝 健康
- 腸内微生物の研究
- 栄養学
背景:
- ダイエット,腸内微生物群,代謝の健康は 肥満やサルコペニアの発達において 極めて重要だと認識されています
- ダイエット-腸内微生物-サルコペニア軸の理解は 標的を絞った介入に不可欠です
研究 の 目的:
- 腸内微生物群の食事指数 (DI-GM) とサルコペニアの流行の関連性を調査する.
- DI-GMとサルコペニアの関係におけるボディ・ラウンドネス・インデックス (BRI) の媒介的な役割を探求する.
主な方法:
- 2011~2018年の全国保健栄養調査 (NHANES) のデータを活用した.
- 多変量重定回帰と制限された立方スライン分析を使用した.
- BRIの役割を評価するために調停分析を実施しました.
主要な成果:
- DI- GMの上昇は,サルコーペニアの罹患率の12%の減少と関連していた (OR=0. 88).
- 有益な腸内微生物群のスコアは,サルコーペニアのリスクを有意に低下させた (OR=0. 82).
- サルコペニアに対するDI-GMの総効果の23%をBRIが媒介した.
結論:
- DI-GMはサルコペニアとネガティブな関連性を示し,BRIは重要な媒介者である.
- 個別化されたサルコペニア管理のための食事と微生物群を対象とした戦略を統合することを支持しています.
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