腹腔鏡手術を受けた患者の術後認知機能障害に対する静脈内リドカインの効果: 2 センター,ランダム化,ダブルブラインド制御試験
Ke-Peng Liu1, Jing Dai2, Fu-Rong Huang2
1Department of Anesthesiology, Zhongshan City People's Hospital, Zhongshan, Guangdong, China.
Current therapeutic research, clinical and experimental
|September 2, 2025
まとめ
腹腔鏡による大腸内外科手術を受けた患者で,静脈内リドカインは,手術後の認知機能を有意に改善しました. この治療は,プロポフォールが部分的に効果を媒介することで,第7日までに術後の認知機能障害 (POCD) の発生率を減少させた.
科学分野:
- 麻酔科
- 神経科学
- 手術腫瘍学
背景:
- 手術後の認知機能障害 (POCD) は,胃腸外科手術後の大きな懸念事項です.
- 術後の認知機能の改善は 患者のリハビリテーションに不可欠です
- 術後の認知機能に対する静脈内リドカインの効果は十分に確立されていません.
研究 の 目的:
- 手術後の認知機能に対する静脈内リドカインの影響を調査する.
- 腹腔鏡による大腸内外科手術を受ける患者におけるリドカインの術後の認知機能障害 (POCD) の影響を評価する.
主な方法:
- 予期的なランダム化試験です
- 腹腔鏡で結腸癌を 切除する患者
- 主要エンドポイント: ミニメンタルステート試験 (MMSE) のスコアと手術後7日のPOCD発生率.
主要な成果:
- リドカイン群では,手術後7日後にPOCDの発生率が著しく低下した (P < 0. 05).
- リドカイン群では手術後7日後にMMSEのスコアが高く見られた (P < 0. 05).
- プロポフォールはPOCDに対するリドカインの効果を部分的に媒介した (10%の媒介).
結論:
- 腹腔鏡による大腸内外科手術の7日後,静脈内投与のリドカインは認知機能を高めます.
- リドカインの投与は,この患者集団におけるPOCDの発生率を低下させる.
- プロポフォールは,リドカインの認知に対する有益な作用の部分的な媒介的な役割を果たします.
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