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Updated: Sep 9, 2025

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

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MDSに関連したSF3B1変異は,メディエーターキナーゼモジュール成分CDK8のミススプライシングを通じて,血液形成幹細胞の異常な運命選択を促進する

Elizabeth A Bonner, Tun-Yun Hsueh, Axia Song

    bioRxiv : the preprint server for biology
    |September 2, 2025
    PubMed
    まとめ

    MDSのSF3B1変異は,血液形成幹細胞と前身細胞の重要なレギュラーであるCDK8の異常スプライシングを引き起こします. このミススプライシングは,リングシデロブラストを持つMDSで細胞運命を変化させ,赤色線維系統の結合を促します.

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