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Updated: Sep 9, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

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Protpardelle-1cを用いた条件付きタンパク質構造生成

Tianyu Lu1, Richard Shuai2, Petr Kouba3

  • 1Department of Bioengineering, Stanford University.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
まとめ

Protpardelle-1cはモチーフ・スカフォールドと多鎖複合体の機能を持つ高度なタンパク質構造生成を提供します. この新しいモデルは,RF拡散のような既存の方法と比較して,性能とサンプリング速度を大幅に改善しています.

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Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
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Protein and Protein Structures02:15

Protein and Protein Structures

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Protein Folding01:22

Protein Folding

Overview
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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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