関連する実験動画

Updated: Sep 9, 2025

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
15:04

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

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アミロイドβと膜の相互作用:結合とアミロイド病理を触媒するために,膜からコレステロールの除去

Rishiram Baral, Ruan van Deventer, Yuri L Lyubchenko

    bioRxiv : the preprint server for biology
    |September 2, 2025
    PubMed
    まとめ

    アルツハイマー病にはコレステロールとアミロイドβ (Aβ42) ペプチドが含まれます. この研究は,Aβ42が膜からコレステロールを抽出し,Aβ42の結合とADの進行を加速することを示しています.

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    A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

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    Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain10:08

    Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

    Published on: August 28, 2012

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    Amyloid Fibrils03:03

    Amyloid Fibrils

    Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
    Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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    Mechanisms of Membrane Domain Formation00:59

    Mechanisms of Membrane Domain Formation

    Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
    Another mechanism for membrane domain formation involves membrane proteins interacting with...
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    Membrane Fluidity01:23

    Membrane Fluidity

    Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
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