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Updated: Sep 9, 2025

Examining the Conformational Dynamics of Membrane Proteins in situ with Site-directed Fluorescence Labeling
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Examining the Conformational Dynamics of Membrane Proteins in situ with Site-directed Fluorescence Labeling

Published on: May 29, 2011

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電圧ゲートされたナトリウムチャネルにおける遅い無活性化の基礎となるコンフォーマーションダイナミクス

Katsumasa Irie, Shuo Han, Sarah Applewhite

    bioRxiv : the preprint server for biology
    |September 2, 2025
    PubMed
    まとめ

    ボルテージゲートナトリウム (Nav) チャンネルでの遅い無活性化には,選択性フィルター孔の崩壊が含まれます. 残留物L176は重要なカップラーとして作用し,毛穴ゲートの形状の変化と遅い無活性化を結びつける.

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