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Updated: Sep 9, 2025

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
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D-アラニンアミノトランスフェラーゼS180F置換は,抗生物質の不活性化により,Staphylococcus aureusにβ-クロロ-D-アラニンに対する耐性を授与する

Rakesh Roy, Yahani P Jayasinghe, Sasmita Panda

    bioRxiv : the preprint server for biology
    |September 2, 2025
    PubMed
    まとめ

    メチシリン耐性黄色のステーキ菌 (MRSA) は,生存と抗生物質耐性のために特定のアラニン代謝経路を必要とします. D-サイクロセリン (DCS) やβ-クロロ-D-アラニン (BCDA) などの抗生物質でアラニンラセメーズ (Alr1) とD-アラニンアミノトランスフェラーゼ (Dat) を標的とすることは,新しい治療戦略を提供します.

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