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Updated: Sep 9, 2025

Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase
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Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase

Published on: March 19, 2020

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単一の触媒ヒスティジン残基を持つ2つのLARA型のニッケル・ピンカー・ヌクレオチド・コファクター利用酵素の構造

Santhosh Gatreddi, Sundharraman Subramanian, Dexin Sui

    bioRxiv : the preprint server for biology
    |September 2, 2025
    PubMed
    まとめ

    LarA酵素は,ニッケルピンチャーヌクレオチド (NPN) コファクターを使用してα-ヒドロキシ酸を触媒化する. ヒスティジン残留物が欠けているいくつかの変種は,新しい構造と基板処理メカニズムを明らかにし,潜在的にそれらの代謝的役割を拡大します.

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