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Updated: Sep 9, 2025

Reconstitution of Msp1 Extraction Activity with Fully Purified Components
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RILPL1とTMEM55Bの結合の構造的基礎は,保存されたTBMモチーフを通してアダプタアセンブリのためのリソソームのプラットフォームを明らかにする

Dieter Waschbüsch1, Prosenjit Pal2, Raja S Nirujogi2

  • 1School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
まとめ

VPS35とLRRK2キナーゼの変異は,Rab GTPaseの高酸化を引き起こし,シグナリング複合体を形成する. TMEM55Bはリソソーム膜の中心のハブとして働き,RILPL1や他のタンパク質を誘導し,新しい規制ネットワークを明らかにします.

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