Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Indirect Motor Pathways01:22

Indirect Motor Pathways

1.7K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.7K
Somatic Spinal Reflexes01:22

Somatic Spinal Reflexes

2.7K
Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
2.7K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

5.9K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
5.9K
Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

1.7K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
1.7K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

2.7K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.7K
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

2.5K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Optogenetic methods to stimulate gamma motor neuron axons ex vivo.

Experimental physiology·2025
Same author

Differential encoding of mammalian proprioception by voltage-gated sodium channels.

Science advances·2025
Same author

Differential encoding of mammalian proprioception by voltage-gated sodium channels.

bioRxiv : the preprint server for biology·2024
Same author

Ion channels of cold transduction and transmission.

The Journal of general physiology·2024
Same author

Computational design of peptides to target Na<sub>V</sub>1.7 channel with high potency and selectivity for the treatment of pain.

eLife·2022
Same author

Na<sub>V</sub>1.1 is essential for proprioceptive signaling and motor behaviors.

eLife·2022

関連する実験動画

Updated: Sep 9, 2025

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons
09:28

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons

Published on: March 8, 2010

8.9K

発達中の脊髄における,補足信号伝達機構による活動主導のシナプス精錬

Chetan Nagaraja1, Serena Ortiz1, Akash R Murali1,2

  • 1Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
まとめ
この要約は機械生成です。

初期の発達期には,自受性Iaアフェレンツが最初は脊髄のセグメントに繋がります. このセグメント間の接続性は,プロピオセプター活動とC1qAシグナル伝達によって導かれ,産後13日までに縮小されます.

さらに関連する動画

Spinal Cord Electrophysiology
04:59

Spinal Cord Electrophysiology

Published on: January 18, 2010

21.6K
Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

9.4K

関連する実験動画

Last Updated: Sep 9, 2025

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons
09:28

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons

Published on: March 8, 2010

8.9K
Spinal Cord Electrophysiology
04:59

Spinal Cord Electrophysiology

Published on: January 18, 2010

21.6K
Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

9.4K

科学分野:

  • 神経科学
  • 発達生物学
  • 脊髄回路

背景:

  • 運動制御に不可欠なプロピオセプティブグループIaアファレントは,脊髄アルファ運動ニューロンとのモノシナプス結合を形成する.
  • これらのアファレントの正確なセグメンタルターゲティングを確立する発達メカニズムは,ほとんど不明である.
  • この特異性を理解することは モーター制御の開発の鍵です

研究 の 目的:

  • モーターニューロンへのプロイオセプティブIAアフェレンスの接続性の発達タイムラインを調査する.
  • セグメント特異性を確立するプロプロイセプター活動の役割を決定する.
  • 過剰なセグメント間接続を排除する分子経路を解明する.

主な方法:

  • 新生児マウスの脊髄製剤におけるex vivo電気生理学
  • アファレントモーターニューロンの接続を特定する解剖学的な追跡.
  • 条件付きノックアウトのNaV1.6とC1qAのノックアウトマウスモデルを分析した.
  • C1qA発現に対する免疫ヒストケミストリー

主要な成果:

  • 自己受容性IAアファレントは,最初はセグメンタルとインターセグメンタルの両方のモノシナプス結合を形成する.
  • 産後初期 (P4-7) において,セグメント間関係は顕著であり,P11-13ではほとんど存在しない.
  • 自己受容体信号の障害 (NaV1. 6 cKO) またはC1qAの欠乏は,セグメント間接続性を延長する.
  • NaV1. 6 cKOマウスのC1qA発現の低下が観察され,その関与が示唆された.

結論:

  • 自己受容性アフェレント接続性の改善に 重要な産後ウィンドウが存在します
  • C1qAによって媒介されるプロリオセプター活動は,過剰なセグメント間接続の除去を促します.
  • このプロセスは,成熟したモーター制御に必要な正確なセグメント特異性を確立します.