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Updated: Sep 9, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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内分泌療法に抵抗する乳がんにおける標的となる脆弱性として,セラミド誘発の内分泌網膜ストレス

Purab Pal1, Shweta Chitkara2, Godwin K Sarpey1

  • 1Department of Physiology and Biophysics, University of Illinois Chicago, IL, USA.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
まとめ

乳がんにおける内分泌療法抵抗は,セラミドの減少とセラミド誘発の細胞死に対する感受性の増加を伴う. セラミドは,PERK経由でエンドプラズマ網膜ストレス (EnRS) 経路を活性化し,特にTRAM1の相互作用により,抵抗性細胞の細胞死を引き起こす.

キーワード:
セラミドセラミドと相互作用するタンパク質内分泌療法に対する耐性エンドプラズマの網膜のストレス乳がん 乳がんPERK (ペーク)トラム1

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