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Updated: Sep 9, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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CRISPR-Cas13d-Mediated Targeting of a Context-Specific Essential

Daniel Stauber1,2, Lucas Sosnick1,2, Yitong Ma1

  • 1Department of Bioengineering, Stanford University, Stanford, CA, USA.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
まとめ

研究者は,CRISPR-Cas13dを用いた新しいRNAターゲティング療法を開発し,大腸内メラノーマにおける重要なRASGRP3遺伝子を静止させました. この画期的な眼がんの 新しく強力な治療法で 生存率を大幅に向上させました

キーワード:
CRISPR-Cas13dについてRNAターゲティングがん治療薬文脈特有の必須遺伝子精度の高い腫瘍標的化メラノーマ

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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
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