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Updated: Sep 9, 2025

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
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エライド酸は,脂質ラフト媒介のIL-1Rシグナル伝達により,細胞老化と炎症を誘発する

Ryota Kojima1, Yusuke Hirata1, Ryo Ashida1

  • 1Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.

iScience
|September 2, 2025
PubMed
まとめ

エライド酸のようなトランス脂肪酸 (TFAs) は,DNA損傷後のIL-1Rシグナル伝達を強化することで,細胞の老化と炎症を促進します. このメカニズムは,代謝機能障害に関連する脂肪性肝疾患 (MASLD) を含む炎症性疾患に寄与する.

キーワード:
生物化学細胞生物学

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