MASLD,β3-

Céline Marie Pauline Martin1, Arnaud Polizzi1, Valérie Alquier-Bacquié1

  • 1Toxalim, Université de Toulouse, INRAE, ENVT, EI-Purpan, Toulouse, France.

iScience
|September 2, 2025
PubMed
まとめ

熱中性ハウジングは,肥満,糖尿病,肝臓損傷を悪化させ,マウスの代謝機能障害に関連する脂肪性肝疾患 (MASLD) を悪化させる. このモデルでは,MASLDにおける肝臓と脂肪組織とのコミュニケーションの欠陥による茶色脂肪組織活性化の障害が示されています.

関連する概念動画

Thermoregulation01:26

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
1.2K
Body Temperature01:25

Body Temperature

The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
2.2K
Mechanism of heat transfer01:19

Mechanism of heat transfer

Understanding heat transfer mechanisms is essential for understanding how our bodies maintain balance in different environmental conditions. When the environment is thermoneutral, the body is in a state of balance, neither using nor releasing energy to maintain its core temperature. However, when the environment is not thermoneutral, the body employs four heat transfer mechanisms to maintain homeostasis: conduction, convection, evaporation, and radiation. These mechanisms facilitate heat...
1.4K
Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
2.0K