食道を超えたエオシノフィール:EoE以外のエオシノフィール性胃腸疾患のレビュー
Angela Y Lam1, Nirmala Gonsalves2
1Department of Gastroenterology and Hepatology, Kaiser Permanente San Francisco, San Francisco, California.
Gastroenterology & hepatology
|September 2, 2025
まとめ
非エオシノフィル性胃腸疾患 (EGID) の診断と管理に関するガイドラインは限られている. このレビューは,エオシノフィル性胃炎,腸炎,大腸炎に焦点を当て,その診断と治療の洞察を提供します.
科学分野:
- 胃腸内科
- 免疫学
- 病理学について
背景:
- エオシノフィル性食道炎 (EoE) は十分に研究されているが,EoE以外のEGIDには診断と管理のガイドラインがない.
- エオシノフィル性胃炎,腸炎,大腸炎を含む非EoE EGIDは,ますます認識されています.
- 非EoE EGIDの希少性と多様性は診断を複雑にし,患者の生活の質に影響を与えます.
研究 の 目的:
- 非EoE EGIDの診断と管理をレビューする.
- 診断の課題と治療の選択肢に 焦点を当てること
- 改善された理解と継続的なガイドライン開発の必要性を強調する.
主な方法:
- EoE以外のEGIDに焦点を当てた文献レビュー
- 診断基準の分析と組織学的評価
- 現在の治療戦略と新たな治療戦略の検討
主要な成果:
- 非EoE EGIDの希少性と異質性により,診断上の課題は残っています.
- ヒストロジカル評価と診断基準は活発に開発されています.
- 効果的な管理は現在の治療法で達成可能であり,より多くの治療法が想定されています.
結論:
- 非EoE EGIDの理解を深めることは極めて重要です.
- コンセンサスな命名法と洗練された診断方法が必要である.
- 現在の管理戦略は有効で 将来の治療法も有望です
関連する概念動画
Barrett Esophagus-II: Clinical Manifestations and Management
292
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
292
Gastroesophageal Reflux Disease II: Clinical Features and Management
156
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
156
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
439
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
439
Esophageal Strictures-I: Introduction
264
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
264
Endoscopic Procedures I: Esophagogastroduodenoscopy
346
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
During an EGD, the endoscope can be used to:
346
Barrett Esophagus-I: Introduction
198
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
198


