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Updated: Sep 9, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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HeLa細胞における有望なJAK2阻害剤としての新しいフロコキシン誘導体の探索:統合ドッキング,QSAR-ML,MDシミュレーション,および実験

Duangjai Todsaporn1, Kamonpan Sanachai2, Chanat Aonbangkhen3

  • 1Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.

Computational and structural biotechnology journal
|September 2, 2025
PubMed
まとめ

新しいフロコキシン (FCC) デリバティブは,子宮頸がん治療のためのジャヌスチロシンキナーゼ2 (JAK2) 阻害剤として有望である. これらの化合物はJAK2を効果的に阻害し,がん細胞死を誘発し,薬剤のような好ましい性質を示し,さらなる治療調査を正当化しています.

キーワード:
実験的な検証JAK2阻害剤機械学習ベースのQSAR

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