米国の中年および高齢者の腸内微生物群と骨粗鬆症の食事指数との関連
Yiming Zhan1, Yuhang Liu2, Jialing Tang1
1Department of Physical Education, Central South University, Changsha 410083, PR China.
Preventive medicine reports
|September 2, 2025
まとめ
腸内微生物群 (DI-GM) の高い食事指数は,米国の成人の骨粗鬆症のより低い罹患率に関連しています. この食事と腸の関係が 骨のミネラル密度や老化による骨の健康に影響を及ぼします
科学分野:
- 栄養学
- 微生物群の研究
- ゲロントロジー
- 骨の代謝
背景:
- 骨粗鬆症は,骨のミネラル密度 (BMD) に影響する年齢に関連する一般的な疾患です.
- 腸内微生物群は栄養吸収,免疫,骨の代謝に影響し,BMDに影響します.
- 食生活は腸内微生物の構成と機能を 大きく左右します
研究 の 目的:
- 腸内微生物群の食事指数 (DI-GM) と骨粗鬆症の罹患率との関連を調べる
- 中年および高齢者の代表的なサンプルで関係を分析する.
- この関連における非線形的な傾向を探求する.
主な方法:
- 2007~2020年の国家健康栄養調査 (NHANES) に参加した7255人のデータを利用した.
- DI-GMは腸内微生物群の健康に関連する14の栄養成分に基づいて計算された.
- 股関節頸部骨密度 (BMD) Tスコア ≤ -2.5 を用いて骨粗鬆症を定義し,多変量ロジスティック回帰および制限立方筋 (RCS) モデルを使用した.
主要な成果:
- DI- GMのスコアが高くなったと,骨粗鬆症の有意な逆相関が示された (OR=0. 91,95%CI=0. 85- 0. 97).
- DI-GMと骨粗鬆症の間の非線形的な関係が観察されました.
- DI- GMの有益な成分に対する高いスコアは,骨粗鬆症の発生率の低下と相関する (OR=0. 85,95%CI=0. 78- 0. 92).
結論:
- DI-GMのスコアが上昇することは,骨粗鬆症の罹患率の低下と有意かつ非線形に関連しています.
- 腸内微生物群を標的とした食生活介入は 骨粗鬆症の予防に 新しい戦略を提示するかもしれません
- これらの発見を確認し,因果メカニズムを明らかにするために,さらなる縦断研究が推奨されます.
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