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Updated: Sep 9, 2025

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
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Published on: October 22, 2020

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IL-17 中和抗体は,喫煙によるCOPDモデルにおける機能的および構造的変化を緩和する

Alyne Riani Moreira1, Camila Uchoa da Silva1, Leticia de Paula Costa Mattos1

  • 1Laboratory of Experimental Therapeutic (LIM 20), Division of Medicine - School of Medicine of Hospital das Clinicas HCFMUSP, Sao Paulo, Sao Paulo, SP, Brazil.

Frontiers in immunology
|September 2, 2025
PubMed
まとめ

慢性閉塞性肺疾患 (COPD) のマウスモデルにおける中和抗体によるインタールイキン-17 (IL-17) ブロックは肺損傷と炎症を逆転させた. これは,IL-17阻害剤がCOPD患者にとって,疾患の発症後でさえ治療の選択肢を提供することを示唆しています.

キーワード:
COPD についてIL-17 阻害剤適応免疫反応呼吸器メカニズム構造的変化

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