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18F-FDG PET/CTで診断され,ステロイド投与によって改善されたPD-1阻害後の再発性多重症:症例報告と文献レビュー

  • 0Respiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang, China.
Frontiers in Immunology +

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2025年9月2日

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2025年9月2日

PubMedで要約を見る

まとめ

この要約は機械生成です。

免疫チェックポイント阻害剤は,まれな自己免疫疾患である再発性多重体炎 (RP) を引き起こします. 18F-FDG PET/CTによる早期診断と迅速なコルチコステロイド治療は,このICI誘発状態の管理の鍵です.

科学分野

  • 腫瘍学
  • リウマトロジ
  • 免疫学

背景

  • 免疫チェックポイント阻害剤 (ICI) はがん治療に使用されます.
  • ICIを受けた患者の最大22%は,免疫関連の有害事象 (irAEs) を経験する.
  • 発症再発性多重症 (RP) を含むリウマティック疾患を模倣する irAEsもあります.

研究 の 目的

  • 抗PD-1療法 (ティスレリズマブ) によって誘発されたRPの症例を報告する.
  • がん患者の薬剤誘発性RPをレビューする.
  • ICI誘発のRPの病原性,診断,治療,および予後を分析する.

主な方法

  • ティセリズマブ治療後のRPの症例報告
  • 診断のために18F-フッ素酸化グルコース陽子放出トモグラフィー/コンピュータトモグラフィー (18F-FDG PET/CT) を利用した.
  • 癌患者の薬物誘発性RPに関する13の出版物の文献レビューを行った.

主要な成果

  • 報告された症例を含め,がん患者における薬物関連RPの14例を分析した.
  • 症状は通常,治療開始から3〜5ヶ月後に現れる.
  • 常見の原発腫瘍部位には,血液系,上部消化器系,皮膚が含まれています.

結論

  • 18F-FDG PET/CTは,PD-1阻害剤に関連したRPの診断に不可欠です.
  • 早期発見と迅速なコルチコステロイド投与は,RPの進行を管理するために不可欠です.
  • 効果的な治療は症状を緩和し,ICI誘発のRPの合併症を予防します.

キーワード:

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