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Updated: Sep 9, 2025

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

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β2GPIのJ形は,ドメインIとドメインIIを横断する神秘的な不連続エピトープを明らかにする

C J Lalaurie1, M Kulke2, N Geist3

  • 1Division of Medicine, Rayne Building, 5 University Street, University College London WC1E 6JF London, United Kingdom.

Journal of structural biology: X
|September 2, 2025
PubMed
まとめ

ベータ2グリコプロテインIは線形に変化し,アンチフォスホリピド症候群における自己抗体結合を増加させる. 分子ダイナミクスは,構造的変化と表皮質の露出を明らかにし,特にプラズミンクリップされた形態です.

キーワード:
APS についてオート抗原エピトープベータ2グリコタンパク質 I分子力学構造生物学

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