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Updated: Sep 9, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

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HCT-116 がん細胞におけるEGFRキナーゼ阻害体としてのピリミジンベースのいくつかの新しいピレン/ベンゾクロメン混合体の合成

Yassin Adam A Mohammed1, Nabila A Kheder1, Mohamed S Nafie2,3,4

  • 1Department of Chemistry, Faculty of Science, Cairo University Giza 12613 Egypt kmdawood@sci.cu.edu.eg (+202) 35727556 (+202) 35676602.

RSC advances
|September 2, 2025
PubMed
まとめ

新しいピリミジン-ピレン混合体および関連化合物は,HCT-116細胞に対する強力な抗がん作用を示し,癌の成長を阻害し,アポトーシスを誘導します. これらの新しい分子は,がん治療のEGFR阻害剤として有望であることが示されています.

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