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Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

252
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
252
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

285
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
285

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Updated: Sep 9, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
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ディペプチジルペプチダゼ-4 阻害剤を投与された患者でCOVID-19 感染症によって引き起こされたブルルス・ペプチゴイドの症例

Mayuka Fukata1, Tomomi Omura2, Keiko Maeda2

  • 1Department of Residency Training, Meitetsu Hospital, Nagoya, JPN.

Cureus
|September 2, 2025
PubMed
まとめ

ディペプチジルペプチダース-4 (DPP-4) 阻害剤は,特にCOVID-19 感染後の糖尿病の高齢者において,ブルース・ペムフィゴイド (BP) のリスクを増加させる可能性があります. 薬物とウイルスと自己免疫疾患の相互作用の可能性を考慮して,注意深いモニタリングが推奨されます.

科学分野:

  • 免疫皮膚科
  • 内分泌学
  • 感染症

背景:

  • ディペプチジルペプチダース-4 (DPP- 4) 阻害剤は2型糖尿病の治療法として一般的です.
  • 新しく懸念されるのは,薬剤誘発性ブルラスペンフィゴイド (BP) との関連である.
キーワード:
自己免疫疾患コロナウイルスdpp4 阻害剤薬剤誘発性ブルラスペンフィゴイド高齢 患者

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