非O1および非O139ビブリオコレラ菌病による急性胆炎:症例報告
Yoshinori Takahashi1, Ryosuke Isshiki1, Hajime Sunagozaka2
1Department of General Medicine and Infectious Diseases, Japan Agricultural Cooperative (JA) Toyama Koseiren Takaoka Hospital, Takaoka, JPN.
Cureus
|September 2, 2025
まとめ
非O1および非O139のビブリオコレラ (NOVC) は,免疫不全の患者で急性胆炎を誘発した. これは,代替的毒性因子を持つNOVC菌株の侵入可能性を強調しています.
科学分野:
- 感染症
- 微生物学
- 臨床医学
背景:
- 急性胆炎と細菌血症は重篤な感染症であり,しばしばグラム陰性細菌と関連しています.
- Vibrio choleraeは一般的にコレラを引き起こすが,O1とO139以外の株 (NOVC) は腸外感染症を引き起こす.
研究 の 目的:
- NOVC菌株によって引き起こされた細菌性急性胆炎を報告する.
- 特定されたNOVC株の毒性遺伝子を特徴付ける.
- 侵襲的なNOVC感染の診断と管理への影響について議論する.
主な方法:
- 76歳の男性患者の症例報告
- 血液培養からVibrio choleraeの分離と識別
- コレラ毒素遺伝子を含む毒性の遺伝子を検出するための分子分析
- 患者の病歴と危険因子の検討
主要な成果:
- 患者にはNOVCによる急性胆炎と細菌血症があり,血清群O120でした.
- NOVC株はコレラ毒素遺伝子を欠いたが,他の毒性遺伝子 (hlyA,rtxA,vscV2,vspD) を有していた.
- 患者のリスク要因には全胃切除術,糖尿病,以前の胆道介入が含まれていた.
結論:
- ノン- O1/ ノン- O139 ビブリオ・コレラは,重度の侵襲性感染症である胆炎や細菌血症を引き起こす可能性があります.
- NOVC菌株の病原性にはコレラ毒素以外のウイルス性要因が寄与する.
- 患者の病歴と適切な培養を考慮した早期診断は,特に免疫不全の宿主において,侵入性NOVC感染の管理に極めて重要です.
関連する概念動画
Acute Pyelonephritis II: Diagnostic Studies and Management
39
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
39
Acute Pyelonephritis I: Introduction
44
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
44
Chronic Pancreatitis II: Collaborative Care
128
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
128
Acute Pancreatitis II: Clinical Manifestations and Management
175
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
175
Acute Pancreatitis I: Introduction
476
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
476
Acute Pharyngitis
1.5K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
1.5K


