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Updated: May 12, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

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皮質 の リーシュマニア 症 の 治療 に 関する 症例 報告

Omar Gerardo Galaviz-Chaparro1, María Fernanda Limón-Limón1, Mariana Ceniceros-Cabrales1

  • 1Dermatology, Instituto Dermatológico de Jalisco "Dr. José Barba Rubio", Zapopan, MEX.

Cureus
|September 2, 2025
PubMed
まとめ

Leishmania mexicanaによって引き起こされる皮膚性リーシュマニアは,経口イトラコナゾールと冷凍療法の組み合わせで効果的に治療できます. このアプローチは,標準的な治療法が利用できない場合,または毒性を引き起こす場合に有効な代替手段を提供します.

キーワード:
冷凍手術皮膚性リーシュマニアイトラコナゾールレイスマニア・メキシコナリーシュマニア

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Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...