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新たに提案された腸内微生物群と糖尿病および前糖尿病患者の全因および心血管疾患による死亡率との関連
Wenjing Song1, Daoqin Liu2, Zihe Xing1
1Department of Laboratory Medicine, The First Affiliated Hospital, Wannan Medical College, Wuhu, Anhui, China.
Frontiers in nutrition
|September 2, 2025
まとめ
より高い腸内微生物群栄養指数 (DI-GM) のスコアは,糖尿病または糖尿病前の患者の死亡率の低下と関連しています. この食事の評価ツールでは,全因性および心血管疾患による死亡リスクとの相反的な関係が示されています.
科学分野:
- 食事の評価と腸内微生物群の相互作用
- 心血管疾患と死亡リスク要因
- 糖尿病と糖尿病前期における健康上の結果
背景:
- 腸内微生物群の食事指数 (DI-GM) は,食事と微生物群の相互作用を定量化するための新しいツールです.
- DI-GMと糖尿病患者または糖尿病前患者における死亡リスクとの関連は未調査のままである.
- この研究は,脆弱な患者集団におけるDI-GMスコアと死亡率の関連性を調査しています.
研究 の 目的:
- DI-GMスコアと全死亡率の縦断的な関係を調べる
- DI-GMスコアと心血管疾患による死亡率との関連を評価する.
- 糖尿病または前糖尿病と診断された患者でこれらの関係を評価する.
主な方法:
- 2007年から2018年にかけて実施された国家健康栄養調査 (NHANES) のデータを活用した.
- 多変数調整されたコックス比例危険性回帰,限定立方スライン (RCS) モデリング,およびサブグループ分析を使用した.
- DI-GMと死亡率に関する発見の信頼性を確保するために,感受性評価を実施した.
主要な成果:
- DI-GMの1単位増加は,全因死亡率の8%減少 (HR=0. 92) と心血管死亡率の11%減少 (HR=0. 89) と関連付けられました.
- 最も高いDI- GM四分の一の参加者は,最も低い四分の一と比較して,すべての原因による死亡率 (HR=0. 74) と心血管疾患による死亡率 (HR=0. 70) を著しく低下させた.
- RCSモデリングは,有益な腸内微生物群スコア (BGMS) が死亡リスクと逆の関連性を示し,負の相関性を確認した.
結論:
- DI-GMスコアの上昇は,糖尿病または前糖尿病患者の全因および心血管疾患による死亡リスクの減少と有意に関連しています.
- これらの発見は,この集団における死亡結果に影響する食事によって調節された腸内微生物群の潜在的な役割を強調しています.
- DI-GMは,糖尿病患者および糖尿病前患者における食事パターンに関連した死亡リスクの評価に役立つかもしれません.
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