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Updated: Sep 9, 2025

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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エクソームシーケンシングデータにおける標的領域間のDNAダメージアーテファクトの一貫した非対称性

Tyler D Medina1,2, Declan Bennett1,3, Cathal Seoighe1

  • 1School of Mathematical and Statistical Sciences, University of Galway, University Road, Galway H91 TK33, Ireland.

NAR genomics and bioinformatics
|September 2, 2025
PubMed
まとめ

オキシダティブダメージはG>T変異を引き起こし,エクソーム配列の鎖非対称性を生み出します. この非対称性は,特にがん研究において,重要な酸化関連G>T変異を示すサンプルによる配列化アーティファクトを示す可能性があります.

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