ネパールの中央病院を訪れる高齢者の心臓病患者における潜在的に不適切な薬剤と薬物相互作用
Roshan Giri1,2, Rajeev Shrestha3, Aatma Rai2
1Pharmaceutical Sciences Program, School of Health and Allied Sciences Pokhara University Pokhara Nepal.
Aging medicine (Milton (N.S.W))
|September 2, 2025
まとめ
潜在的に不適切な薬剤と薬物相互作用は,高齢の心臓患者で一般的です. これらを減らすことで 健康状態が改善され 費用も削減できます
科学分野:
- 老年薬理学
- 心臓病科
- 臨床薬局
背景:
- 潜在的に不適切な薬 (PIM) と薬物相互作用 (DDI) は,高齢者の患者にとって重大なリスクをもたらす.
- これらの問題は特に心疾患の高齢患者において懸念され,健康上の結果に影響を与えます.
研究 の 目的:
- ネパールの医療機関で PIMとDDIの患者を評価する.
- この集団におけるPIMとDDIの予測要因を特定する.
主な方法:
- 140人の老年患者 (≥65歳) を対象とした前向きの横断試験.
- PIMの評価にはビースの基準,DDIの識別にはMedscapeのソフトウェアが使用された.
- PIMとDDIの予測要因を決定するために,回帰分析を使用した.
主要な成果:
- 患者の23. 6%がPIMを受け,65%がDDIを経験した.
- 陽子ポンプ阻害剤 (PPI) は,最も頻繁なPIMであり,DDIに関与していました.
- 処方された薬の数は,PIM (OR: 1. 352) とDDI (OR: 2. 217) の両方の有意な予測指標でした.
結論:
- PIMとDDIの高い罹患率は,外来心臓病の高齢者の間で存在しています.
- 定期的な薬剤検査と 根拠に基づいた処方箋は 薬剤療法と患者の安全性を最適化するために 極めて重要です
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