N- アセチルグルコサミニルトランスフェラーゼVは,インスリン類似成長因子1受容体のシグナル伝達経路を媒介することによって,心筋梗塞を緩和する

Tianqi Chang1, Yangya'nan Jin2, Chenyu Fan1

  • 1Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University, Beijing, China.

まとめ

N- アセチルグルコサミニルトランスフェラーゼV (GnT- V) は,N- グライコシレーションを調節し,心筋梗塞 (MI) の後の心臓機能を改善します. 過剰発現したGnT-VはIGF1R経路を活性化させ,潜在的にMI治療の戦略となる.

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