ラクトバシルス・プランタラムとラクトバシルス・ブレヴィスは,腸内毒性大腸菌による腸内炎症を和らげ,小豚の腸内微生物と血清代謝産物を安定させる
Xuebing Han1, Rong Gao1, Sujuan Ding1
1College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, Hunan 410128, China.
Animal nutrition (Zhongguo xu mu shou yi xue hui)
|September 2, 2025
まとめ
2つのプロバイオティクスはラクトバチルス・プランタラムとラクトバチルス・ブレヴィスで,腸毒性大腸菌 (ETEC) の下痢からブタを保護することが判明しました. これらのプロバイオティクスは代謝産物と遺伝子発現を調節することで 体重増加と腸の健康を改善しました
科学分野:
- 獣医学
- 微生物学
- 動物の栄養
背景:
- エントロトキシゲン性大腸菌 (ETEC) は,離乳豚に重大な下痢を引き起こします.
- 口服用プロバイオティクスは,豚のETEC誘発性腸内疾患の管理のための重要な戦略です.
- 特定のプロバイオティクスの株のETECに対する有効性の調査は,豚の健康にとって極めて重要です.
研究 の 目的:
- 小豚のETECによる損傷に対するLactobacillus plantarumとLactobacillus brevisの保護効果を評価する.
- これらのプロバイオティクスが小豚の成長能力と小豚の健康に与える影響を評価する.
- 代謝と遺伝子発現の変化を含む,プロバイオティクスの投与によって影響を受ける根本的なメカニズムを探求する.
主な方法:
- ランダム化制御試験では,対照群,ETEC,ETEC+L. plantarum,ETEC+L. brevisの4つのグループに分けられた 24匹のブタを対象とした.
- 21日間の実験期間中,毎日の体重増加と頭蓋骨の整体性を評価した.
- 血清代謝学,トランスクリプトーム配列,および16S rRNA配列が治療効果を分析するために使用されました.
主要な成果:
- L. plantarumとL. brevisは,ETECが毎日の体重増加に与える悪影響を軽減し,乳首の損傷を予防しました.
- L. brevisは,毎日体重増加を著しく増加させ,L. plantarumは同様のポジティブな傾向を示した (P=0. 063).
- 腸内微生物のバランスを維持しながら,有益な血清代謝産物および調節された遺伝子発現 (例えば,LBH,RNASE1) を増加させた.
結論:
- ラクトバチルス・プランタラムとラクトバチルス・ブレヴィスは,小豚のETEC誘発性下痢に対する有意な保護効果を示しています.
- これらのプロバイオティクスは,代謝とトランスクリプトミックの調節を通して,小豚の成長と腸の健康を促進します.
- プロバイオティクスの投与は健康な腸内微生物群をサポートし,豚のETEC予防に有効なアプローチを提供します.
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