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スキサンドラ・チネンシス (Schisandra chinensis) のリンガン系エキスは,腸内微生物群とトリプトファンの代謝を調節することで,アルコール関連肝疾患を予防します
Yan-Yu Chi1, Jun-Yan Xiang2, Hui-Min Li1
1Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin, 130012, China.
Current research in food science
|September 2, 2025
まとめ
Schisandra chinensis lignansは,腸内微生物群とトリプトファンの代謝を回復することにより,アルコール関連肝疾患 (ALD) を予防します. この介入は腸のバリア機能を強化し,肝臓の損傷を軽減し,ALDの予防のための機能的な食物アプローチを提供します.
科学分野:
- ヘパトロジー
- 微生物学
- 薬理学について
背景:
- アルコール関連肝疾患 (ALD) は,世界的な健康問題です.
- 腸内微生物の乱生は,ALDの病原性に関与しています.
- Schisandra chinensis lignans (SCL) は肝臓保護効果を示しているが,ALDに対するメカニズムは不明である.
研究 の 目的:
- マウスにおけるアルコールによる肝損傷に対するSCLの予防効果を評価する.
- 腸内微生物群と腸内代謝産物に対するSCLの影響を調査する.
- SCLの肝臓保護作用の背後にあるメカニズムを解明する.
主な方法:
- 慢性的なエタノール摂取によって誘発されたALDのマウスモデル.
- 様々な用量でのリグナンに富んだシサンドラ・キネンシス (SCL) の抽出物による介入
- 16S rDNAシーケンシングと腸内物質の非標的代謝分析
- 主要な代謝物質と微生物経路のインビボおよびインビトロ検証
主要な成果:
- SCL投与はアルコールによる肝損傷を緩和し,腸の障壁機能を回復させた.
- SCLは腸内トリプトファン (Trp) の代謝を調節し,インドル3酸 (IAA) のレベルを上昇させた.
- SCLはLactobacillus reuteriを濃縮し,IAAの回復とAHR経路の再活性化に貢献し,肝臓の損傷を軽減しました.
結論:
- SCLは腸内微生物群とTrp代謝を調節することでALDを効果的に予防します.
- このメカニズムは,L. reuteriによるIAAの回復,AHR経路の活性化,および腸壁の健全性の強化を含む.
- SCLはALDの予防に有望な機能的な食品です.
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