神経認知プロセスの計算上の測定に Δ9 - テトラヒドロカンナビノールの急性効果は,最近の大麻の使用と関連しています
PubMedで要約を見る
まとめ
この要約は機械生成です。デルタ9テトラヒドロカンナビノール (THC) は認知能力を急激に低下させ,特に大麻の使用歴が少ない個体において, THC投与後の認知能力の低下とも関連しています.
科学分野
- 神経科学
- 精神薬学
- 認知心理学
背景
- 大麻とデルタ9テトラヒドロカンナビノール (THC) は神経認知を損なうと広く考えられている.
- 神経認知に対する急性THC効果に関する以前の研究は 矛盾する結果をもたらした.
- 大麻使用歴と主観的な薬物使用経験の個別の違いがこれらの矛盾を説明する可能性があります.
研究 の 目的
- コンピュータモデリングを用いて神経認知プロセスにTHCの急性効果を調査する.
- 大麻の使用歴と主観的な薬物効果の個々の違いが,THCの認知への影響をどのように変化させるかを調べる.
主な方法
- 30人の健康な若者を対象とした ダブルブラインド・プラセボ対照実験です
- 7. 5mgのTHCまたはプラセボを口服する.
- 認知効率,応答注意,運動実行を評価するために,ドリフト拡散モデリングで分析されたGo/No Goタスクを使用した.
- 神経認知のパラメータと大麻使用歴や主観的な薬物効果などの共変数との関係を分析するためのベイジアン統計です.
主要な成果
- THCはプラセボと比較して,全体的な神経認知のパラメータを有意に変化させなかった.
- THCは認知能力 (ドリフト率) と運動応答の実行 (非決定時間) の個別の変動を増加させた.
- 前回の大麻使用が少ない参加者の認知能力はTHCによってより低下しました.
- より強い主観的な薬物効果 (例えば"高") は認知能力の低下と関連していた.
結論
- 急性THC投与は神経認知,特に認知能力に異質な影響を及ぼします.
- THCによる認知能力の低下は,大麻使用歴と主観的な薬物経験と関連しています.
- 大麻への耐性は,THCの急性認知効果を軽減する可能性があることが示唆されています.
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