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Updated: Sep 9, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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クキュルビタシンBによるSTING依存DNA損傷経路の誘導は,骨肉腫における免疫療法の有効性を高めます

Bin Luo1, Qing Lu2, Qiang Wang1

  • 1Department of Orthopaedics, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu 215500, China.

Iranian journal of basic medical sciences
|September 2, 2025
PubMed
まとめ

クキュルビタシンB (CuB) は,がんDNAを損傷し,免疫反応を活性化することで,骨肉腫に対する有望な効果を示しています. CuBを抗PD- L1療法と併用すると,腫瘍抑制効果がさらに強化されます.

キーワード:
クキュルビタシンBDNA 損傷オステオサルコマPD-L1 についてcGAS-STING経路について

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