アルツハイマー病の神経病理学と主観的認知の変化

Alisa Bannerjee¹, Wendy Elkins¹, Susan M Resnick¹

¹Laboratory of Behavioral Neuroscience National Institute on Aging Baltimore Maryland USA.

Alzheimer's & dementia (Amsterdam, Netherlands)

|September 2, 2025

まとめ

正常な成人の主観的な認知症状は,アルツハイマー病の潜在的なバイオマーカーである早期のタウ病の兆候である. この発見は苦情が客観的な認知機能低下に先行し早期発見の機会を提供することを示唆しています

科学分野:

神経科学
神経学
バイオマーカー

背景:

主観的な認知の苦情は客観的な認知の衰退に先行します
アルツハイマー病 (AD) の神経病理学的早期発見は極めて重要です.
認知的に正常な個人は早期にADに関連する変化を呈することがあります.

研究の目的:

アミロイドとタウの病理と主観的な認知の苦情との関連を調査する.
主観的な苦情が認知的に正常な個人の神経病理学的早期指標として機能するかどうかを判断する.

主な方法:

ボルチモア長期老化研究で 91人の認知的に正常な被験者を調べました
アミロイドベータとタウの病態を測定するためにポジートロン放出トモグラフィー (PET) を使用した.
主観的な苦情と記憶に関する縦断データを分析するために,線形混合効果モデルを使用した.

主要な成果:

パラヒポキャンパスのタウの増加は,主観的な認知障害の増加と相関する.
エントルヒナル・タウの増加は,時間が経つにつれて苦情の増加が遅かった.
ヒッポカンパのタウは記憶の減少に繋がりました

結論:

主観的な認知の苦情は,認知的に正常な個体における早期の脳タウ病理を反映する可能性があります.
タウ病理は,特にパラヒポカンプス領域では,主観的な認知変化と関連しています.
主観的な苦情は初期のアルツハイマー病の非侵襲的なマーカーとして機能します

キーワード:

カリフォルニアの言語学習テスト認知障害に関するアンケートアミロイドβ ポジトロン放出トモグラフィータウ

さらに関連する動画

12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.5K

07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K

関連する概念動画

01:26

Alzheimer's Disease: Overview

666

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

666

01:30

Dementia

165

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....

165

01:22

Alzheimer's Disease: Treatment

260

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

260

01:30

Cognitive Development During Adulthood

255

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

255

01:03

Long-term Depression

2.6K

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...

2.6K

01:37

Neural Regulation

39.9K

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.