関連する実験動画

Updated: Sep 9, 2025

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System
05:28

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

Published on: August 15, 2019

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空気汚染粒子が鼻腔を通って脳に浸透するメカニズムと潜在的な神経学的健康リスクに関する研究

Yi Zhang1, Haitong Zhang2, Haiyan Li2

  • 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China; Weifang Yidu Central Hospital, No. 4138 Linglongshan South Road, Qingzhou City, Weifang City, Shandong Province 262550, China.

Ecotoxicology and environmental safety
|September 2, 2025
PubMed
まとめ

空気中のナノ汚染物質は,メソポラスシリカナノ粒子 (MSN) のように,中枢神経系 (CNS) に入ることができます. 液体汚染物質との同時曝露はMSNの侵入を促進し,脳細胞の完全性を破壊します.

キーワード:
カルキュモール環境MSN についてメントール鼻の脳への侵入

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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols15:04

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The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
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The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
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Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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