主要予防コホートにおける心臓血管の健康状態と長期的な結果における性差
Maneesh Sud1, Areeba Chaudhry2, Feng Qui3
1Schulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; ICES, Toronto, Ontario, Canada; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
JACC. Advances
|September 2, 2025
まとめ
心血管疾患 (CVD) が発症するリスクは男性より高い. これは,心臓血管の健康を改善し,将来の出来事を防ぐために,性別の戦略の必要性を強調しています.
科学分野:
- 心臓病科
- 公衆衛生
- 健康 に 関する 性別 の 違い
背景:
- 心血管疾患 (CVD) は8つの重要な要因によって定義される.
- 現存する研究は,この関連が男性と女性の間で異なっているかどうかを明らかにしていない.
研究 の 目的:
- 心血管の健康状態とCVDイベントの関係が性別によって異なるかどうかを調査する.
- 適した公衆衛生介入の証拠を提供すること.
主な方法:
- 前例のCVDのない175,098人の成人のオンタリオ保健研究 (2009年−2017年) の分析.
- 心血管の健康は理想的な食事,睡眠,運動,喫煙,体量指数,血糖,コレステロール,血圧で評価される.
- 健康状態とCVDイベントの間の関連性を評価するために使用されたコックスの比例リスクモデル.
主要な成果:
- 女性は男性 (4. 6%) よりも理想的な心血管健康率 (9. 1%) を有し,心血管健康率の低下 (21. 9% 対 30. 5%) を有していた.
- 心血管疾患のリスク比は,中等 (2. 31) と貧弱 (5. 08) の女性では男性に比べて有意に高かった (1. 57 と 2. 54).
- 重要な相互作用期間 (P < 0. 01) は,女性におけるCVDリスクに対する心臓血管の健康状態の低下によるより大きな相対的な影響を示した.
結論:
- 心血管の健康状態の低下は,男性に比べて女性の将来のCVD率により大きな相対的な影響を及ぼします.
- 性別別別別の健康促進戦略を開発し,心臓血管の健康を向上させ,結果を改善することを支援しています.
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