遠腸がん患者の測定および予測されたエネルギー消費:GAINプロジェクトの結果
Benedicte Beichmann1, Eli P Sollerud2, Nicole Sonja Warmbrodt3
1Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway; Section of Clinical Nutrition, Department of Clinical Service, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway.
Clinical nutrition (Edinburgh, Scotland)
|September 2, 2025
まとめ
標準的な方程式では 新しいがん患者の エネルギー需要を過小評価しています 総エネルギー消費量 (TEE) は 30 kcal/kg/day の目標が提案されていますが,個別の変動が大きいため,注意深くモニタリングすることが重要です.
科学分野:
- 腫瘍学
- メタボリズム
- 栄養学
背景:
- 精密なエネルギー消費の見積もりは 癌患者の管理に不可欠です
- 既存のエネルギー需要の予測方程式は,健康な集団で検証されることが多い.
- 癌患者の栄養状態は,代謝需要に大きな影響を与える可能性があります.
研究 の 目的:
- 測定された休息時のエネルギー消費 (REE) と,新たに診断された遠腸がん患者の予測値を比較する.
- 計測された総エネルギー支出 (TEE) とESPENの勧告の一致性を評価する.
- この特定の患者グループにおける REEの予測方程式の正確性を評価する.
主な方法:
- 新しく診断された40人の腸内がん患者の横断研究.
- 休憩時のエネルギー消費量 (REE) は,間接的カロリメトリー (COSMED Q-NRG) で測定される.
- 5つの標準予測方程式とESPEN TEEの推奨値 (25-30 kcal/kg/日) で測定されたREEの比較
主要な成果:
- すべての試験式は,がん患者で測定されたREEを過小評価し,合意の範囲は広い.
- WHO/FAO/UNUの方程式は,合意の最も狭い,しかしまだ広い限界を示しました.
- TEEの目標値である30 kcal/kg/dayは,個別の有意な変動にもかかわらず,25 kcal/kg/dayよりも測定値とよく一致していた.
結論:
- 標準的なREE予測方程式は,新たに診断された遠腸がん患者では不正確です.
- 30 kcal/kg/dayの TEE 目標は適切かもしれませんが,個別の監視が必要です.
- エネルギー消費量の大きな変動は,負のエネルギーバランスを防ぐために慎重に臨床的評価を行う必要があります.
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