関連する実験動画

Updated: Sep 9, 2025

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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コードからコンプレックス:AI主導のデノボ・バインダー設計

Daniel R Fox1, Cyntia Taveneau2, Janik Clement3

  • 1Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Centre for Electron Microscopy of Membrane Proteins, Monash Institute of Pharmacological Sciences, Parkville, VIC 3052, Australia; AI Protein Design Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.

Structure (London, England : 1993)
|September 2, 2025
PubMed
まとめ

構造生物学における人工知能は,新しいタンパク質を作るための de novo タンパク質設計を可能にします. 機械学習は 難問な標的に対する 高親和結合体の開発を加速し タンパク質工学に革命をもたらします

キーワード:
アルファフォールド2ビンドクラフトクロマデノボのタンパク質設計タンパク質MPNNRF拡散ローズ フォールド人工知能計算式タンパク質設計de novo タンパク質結合剤生成的な拡散モデル幻覚塗装する機械学習ニューラルネットワーク

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関連する概念動画

Ligand Binding and Linkage00:49

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Conserved Binding Sites

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Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

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Ligand Binding Sites

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The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

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PD Controller: Design01:26

PD Controller: Design

In automotive engineering, car suspension systems often employ Proportional Derivative (PD) controllers to enhance performance. PD controllers are utilized to adjust the damping force in response to road conditions. A controller, acting as an amplifier with a constant gain, demonstrates proportional control, with output directly mirroring input.
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
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