肥満,代謝健康,脳健康:前向きなコホート研究からの洞察
PubMedで要約を見る
まとめ
この要約は機械生成です。代謝的に健康的な肥満 (MHO) は脳卒中,不安,うつ病のリスクを高めます. 認知症のリスクは 肥満そのものではなく 代謝不健康と関連しており 体重と代謝の健康が 脳の健康に大きく影響します
科学分野
- 神経学
- 代謝 健康
- 肥満に関する研究
背景
- 代謝的に健康的な肥満 (MHO) は心臓血管リスクと関連しているが,神経学的および精神的健康への影響は不明である.
- この研究では,代謝性肥満のフェノタイプと脳関連の疾患との関連を調査しています.
研究 の 目的
- 異なる代謝性肥満現象と 神経学的および精神的健康障害のリスクとの関連を調査する.
- 代謝の健康と肥満が脳の健康に与える影響を明らかにする.
主な方法
- 英国バイオバンク参加者318,103人を対象とした人口ベースの前向きなコホート研究で,追跡期間の中央値は13. 2年であった.
- 代謝的に健康な肥満 (MHO) は,BMI ≥30kg/m2と6つの代謝バイオマーカーのうち≥4によって定義される.
- コックス回帰モデルは,代謝性肥満のフェノタイプと脳卒中,不安,うつ病,双極性障害,認知症,パーキンソン病 (PD) の間の関連性を分析した.
主要な成果
- 代謝的に健康な肥満者 (MHO) は,代謝的に健康な非肥満者 (MHN) に比べて,脳卒中 (HR 1. 11),不安 (HR 1. 16),うつ病 (HR 1.43) のリスクが著しく高かった.
- 代謝的に不健康な非肥満 (MUN) および代謝的に不健康な肥満 (MUO) 群も脳卒中,不安,うつ病のリスクが高かった.
- 65歳未満のMUNおよびMUO群では,肥満のみではなく代謝不健康と関連した認知症のリスクの増加が観察されました.
結論
- MHOとMUOは,脳卒中,不安,うつ病のリスクの増加と関連しています.
- 肥満状態に関係なく 認知症のリスクは 代謝的に不健康な状態と強く関連しているようです
- 代謝の健康と 正常な体重の両方を維持することは 脳全体の健康を改善するために 極めて重要です
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