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Updated: Sep 9, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
09:38

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

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EGFR-変異性非小細胞肺がんにおける表皮成長因子受容体チロシンキナーゼ阻害剤に関連した心血管疾患: 系統的レビューとネットワークメタ解析

Zidong Ma1, Fei Cao1, Mingjuan Liao2

  • 1Department of Oncology, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453100, Henan, China.

BMJ (Clinical research ed.)
|September 2, 2025
PubMed
まとめ

第1代および第3代表皮成長因子受容体 (EGFR) タイロシンキナーゼ阻害剤は,EGFR変異性非小細胞肺がん (NSCLC) 患者の心血管リスクを増加させる. 第3世代の阻害剤は,第1世代の阻害剤よりも著しく高いリスクを示します.

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Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Major types that are helpful drug targets include:
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