デンマークにおける認知症のリスク要因の流行と同時発生:全国的な研究

Janet Janbek¹, Thomas Munk Laursen², Kasper Jørgensen¹

¹Danish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital- Rigshospitalet. Blegdamsvej 9, Copenhagen Ø 2100, Denmark.

The journal of prevention of Alzheimer's disease

|September 2, 2025

まとめ

認知症の危険因子はしばしば同時発症し,82%の人が複数発症しています. これは認知症のリスクを効果的に減らすために多領域介入の必要性を強調しています

科学分野:

ゲロントロジーと公衆衛生
神経変性疾患の流行病学

背景:

認知症の危険因子の共存は公衆衛生上の重大な問題です
これらの危険因子の流行とパターンを理解することは効果的な予防戦略を策定する上で極めて重要です

研究の目的:

認知症の危険因子の16の流行を決定する.
大きな集団におけるこれらの危険因子の共存パターンを分析する.

主な方法:

デンマーク全国の1969年~1977年の健康データを用いた横断的な研究で,コホートは2022年1月1日に評価された.
デンマークの65歳以上の全人口と,2010/2013年のデンマーク国民健康調査からのサブ人口を含みます.
個々の危険因子とその組み合わせ (≥10%の発生率) を計算し,診断されたまたは治療された状態を反映した.

主要な成果:

人口の82%が多発性認知症の危険因子を示し,5%だけが無症候群でした.
高血圧は最も一般的なリスク因子で (57%),視力障害は最も少ない (2%).
男性,85歳以上,低学歴者においてリスク因子の有病率が高かった.

結論:

クラスター型認知症の危険因子の高い流行は,包括的で多領域の介入の必要性を強調しています.
複数の要因を同時に取り扱う統合的アプローチへの移行を支持しています

キーワード:

同時に発生する認知症全国的に人口ベースリスク要因

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