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STAT6の標的型剥奪は,生体内および体内におけるサイトラビンに対する急性リンパ性白血病細胞を感知させる:臨床的影響

Shuzhang Sun1, Yixuan Cheng1,2, Xiange Huang2

  • 1Institute of Traditional Chinese Medicine Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Cell death & disease
|September 2, 2025
PubMed
まとめ

再発した急性リンパ性白血病 (ALL) は,STAT6の発現が低下しています. STAT6またはSENP3をターゲットにすると,ALL細胞はサイトラビン (Ara- C) に敏感になり,化学抵抗を克服します.

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