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Updated: Sep 9, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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ウビキチンリガゼHUWE1による薬剤のような小分子の選択的ユビキチン化

Barbara Orth1, Pavel Pohl1, Florian Aust1

  • 1Max Planck Institute for Multidisciplinary Sciences, Research Group 'Ubiquitin Signaling Specificity', Göttingen, Germany.

Nature communications
|September 2, 2025
PubMed
まとめ

ヒトのリガゼHUWE1は タンパク質だけでなく 薬剤の小さな分子も 変化させることができます この発見により 薬の開発にユビキチン系を活用する 新しい方法が明らかになりました

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