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Updated: Sep 9, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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SOX2は,脂質代謝とヒストンのアセチル化パターンを再プログラムすることで,食道状がんを誘発する

Zhen Wang1,2, Ruofei Dai3, Li Kang4

  • 1Shanghai Key Laboratory of Regulatory Biology, Fengxian District Central Hospital-ECNU Joint Center of Translational Medicine, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. zhenwang@sdfmu.edu.cn.

Nature communications
|September 2, 2025
PubMed
まとめ

SOX2は,AKTシグナル伝達とは独立したプロセスであるヒストンのアセチル化を増加させることで,状がんを誘発する. このオンコドライバーは脂質代謝を再プログラムし,食道状細胞がんにおけるスーパーエンハンサー機能を強化します.

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