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Updated: Sep 9, 2025

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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モルヒネと新しいミュオピオイド受容体アゴニスト,クルキノリンとクルキノールの抗ノシセプティブおよび副作用プロファイルにおけるβ-アレスティン2の役割

Ross van de Wetering1, Amy F Alder1, Andrew Biggerstaff1

  • 1School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington, 6012, New Zealand.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
|September 2, 2025
PubMed
まとめ

ベータアレスティン2 (βArr2) 信号は,ミュオピオイド受容体 (MOR) の副作用や耐性を誘導するものではありません. この研究では,ノックアウトマウスを用いて,MOR媒介の鎮痛と副作用におけるβArr2の役割を調査し,Gタンパク質バイアスアゴニストに対する支持は限られている.

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