妊婦の甲状腺ホルモン濃度と環境からのフタラートへの曝露との関連
Lin Tao1,2,3, Shimin Xiong1,2, Lulu Dai1,2,4
1School of Public Health, Zunyi Medical University, Zunyi, 563000, Guizhou Province, China.
Archives of toxicology
|September 2, 2025
まとめ
妊婦が妊娠中にフェタル酸エステル酸 (PAE) に曝露すると,甲状腺ホルモンが影響されます. この研究では,PAEが母親の甲状腺機能を乱すことを示唆する線形でない効果と,投与量と反応の関係が発見され,曝露の減少とモニタリングが必要となった.
科学分野:
- 環境 健康
- 内分泌学
- 生殖毒学
背景:
- フェタラート (PAE) は,妊娠中の母親の甲状腺ホルモンに議論の余地のある内分泌系を乱す化合物である.
- 妊婦の甲状腺機能に対するPAEの影響を理解することは,妊婦と胎児の両方の健康にとって極めて重要です.
研究 の 目的:
- 妊娠中の女性の尿中のPAE代謝産物と血清の甲状腺ホルモンの関係を調査する.
- PAEの曝露と母体の甲状腺ホルモンのレベルとの間の線形でない関連性を明らかにする.
主な方法:
- PAEの代謝産物と甲状腺ホルモンの間の相関性を評価するために,線形混合効果モデル (LMM) を利用した.
- 制限された立方スライン (RCS) 解析を用いて,用量反応の評価を行った.
- 総合的および非線形効果を特定するために,ベイジアンカーネルマシン回帰 (BKMR) を適用した.
主要な成果:
- PAEのいくつかの代謝産物 (MMP,MEHP,MECPP,MIBP,MOP,MBZP) はトータルチロキシン (TT4),フリートリヨドチロニン (FT3),フリーチロキシン (FT4) と相関関係を示した.
- RCS分析では,MEHP,MBZP,MIBPが有意な貢献者であることを確認した.
- BKMRは,PAEの曝露と母親の甲状腺ホルモンの間の反転したU形,非線形関係を明らかにした.
結論:
- 妊婦が妊婦の甲状腺ホルモン分泌に悪影響を及ぼします.
- 妊娠中にフタラートへの曝露を最小限に抑えることが重要であることを強調しています.
- PAEに曝露した妊婦の甲状腺ホルモンの濃度を注意深くモニタリングすることが推奨されます.
関連する概念動画
Synthesis and Regulation of Thyroid Hormones
5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
Teratogenicity
2.7K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.7K
Functions of Thyroid Hormones
3.1K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.1K
Types of Toxins
2.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
2.0K
Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K


