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Updated: Sep 9, 2025

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
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Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

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細胞膜のコレステロールは,変異したトランスポーターオリゴメリゼーションにより,セロトニントランスポーター流出に影響する

Deborah Rudin1, Dino Luethi1,2, Marco Niello1,3

  • 1Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Molecular psychiatry
|September 2, 2025
PubMed
まとめ

コレステロールの減少はモノアミントランスポーター (MAT) の機能を低下させ,吸収と結合親和性を低下させます. これはトランスポーター構成とSERTの小分子化に影響し,SERT経由でアンフェタミン排出量を選択的に増加させる.

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