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Updated: Sep 9, 2025

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
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STINGとリンフォトキシンβ受容体の同時活性化により,三次リンパ性構造のB細胞反応が誘発され,抗腫瘍免疫が強化される

Junko Sawada1, Yasuhiro Kikuchi1, Maxwell Duah1

  • 1Cancer and Blood Disorders Institute, Institute for Fundamental Biomedical Research, and Department of Surgery, Johns Hopkins All Children's Hospital, and Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, St. Petersburg, FL, USA.

Nature immunology
|September 2, 2025
PubMed
まとめ

STINGとリンパ毒素β受容体 (LTβR) の経路を同時に活性化すると,抗腫瘍免疫を強化し,長期的な生存を改善する三次リンパ性構造 (TLS) が形成されます. STINGの活性化だけでは,これらの治療効果は得られなかった.

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