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胃食道逆流症と内臓および腹部の下皮脂肪組織の性別の関連性:大規模な視野コホート研究
Xinyang Liu1,2, Xinyue Li1,2, Mengjiang He1,2
1Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
BMC gastroenterology
|September 2, 2025
まとめ
腹部脂肪組織 (VAT) と腹部皮下脂肪組織 (ASAT) を含む腹部肥満は,胃食道逆流症 (GERD) と関連しています. 性別がGERDのリスクに影響を及ぼすことを示唆しています.
科学分野:
- 代謝 健康
- 胃腸内科
- 流行病学について
背景:
- 以前の研究では,腹部肥満と胃食道逆流症 (GERD) の間に関連があることが示されています.
- しかし,性別による体格の違いとそのGERDリスクへの影響は十分に調査されていません.
研究 の 目的:
- 腹部脂肪組織の成分とGERDの発生率の性別特有の関連性を調査する.
- 腹部脂肪組織 (VAT) と腹部皮下脂肪組織 (ASAT) が男性と女性のGERDリスクに異なった影響を及ぼすかどうかを判断する.
主な方法:
- VATとASATの詳細な磁気共鳴画像 (MRI) 測定を伴う35,009人の英国バイオバンクデータを活用した.
- 腹部脂肪の指標とGERDの関連性を分析するために,コックスの比例リスクモデルを使用しました.
主要な成果:
- 女性のGERDのリスクが高かった.
- 男性では,ASATではなく,VATのみが,GERDリスクの増加と有意な関連性を示した.
- 男性のGERDの発生率は最も低い脂肪の三角体において高かったが,女性では腹部脂肪の増加によるリスク上昇がより顕著であった.
結論:
- 腹部脂肪成分とGERDの間でポジティブな関連性があり,特に女性ではより強い効果が観察されました.
- 性別はGERDのリスク評価と管理において重要な要因であり,より広範な集団でのさらなる調査を正当化しています.
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